A New S-test for Haplotype Analysis: Concordance and Discordance
نویسندگان
چکیده مقاله:
A new test of inheritance, S, is proposed, which uses information from affected as well as unaffected siblings in the fam­ ily. The siblings are analyzed in terms of similarities of haplotypes. The distribution of the proposed S­test is derived under the null hypothesis of random inheritance. Mean and variance are obtained for the distribution. The test is then applied to data sets published in the literature. The results suggest some sort of linkage between haplotypes and disease genes.
منابع مشابه
Test S of Haplotype Concordance and Discordance
The test presented here is based upon the proband and his/her affected as well as unaffected siblings. Here, the siblings are analyzed in terms of similarities of haplotypes. The proposed ‘S’ test is used in testing hypothesis that a particular disease has random pattern of inheritance against the alternative hypothesis that it has non-random pattern of inheritance. Probability distribution, me...
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عنوان ژورنال
دوره 2 شماره 2
صفحات 187- 196
تاریخ انتشار 2006-03
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